Our case indicated that COVID-19 might trigger an autoimmune response that leads to MOG antibody-associated ON, similar to other pathogens that were reported in the past. Outpatient follow-up 2 weeks later revealed left a decimal vision of 1.2, and a complete resolution of the left eye pain. His left eye pain was immediately relieved, and his decimal vision improved from 0.03 to 0.1 on the day of discharge. Steroid pulse therapy consisting of methylprednisolone 1 g/day for a total of 3 days, followed by an oral prednisolone taper was performed. The patient was diagnosed with MOG antibody-positive acute ON possibly induced by COVID-19. Laboratory testing revealed that MOG immunoglobulin G (MOG IgG) was positive, but other antibodies including aquaporin-4 were negative. He tested positive for COVID-19 by polymerase chain reaction (PCR) testing on the day of admission but he had no signs of respiratory illness. Magnetic resonance imaging of the orbit revealed the bilateral high intensity of the optic nerve sheaths. Patient concerns:Ī 47-year-old man presented to our clinic with left eye pain and vision loss. We report a case of acute optic neuritis (ON) associated with myelin oligodendrocyte glycoprotein (MOG) antibody possibly induced by COVID-19. ![]() It involves multiple organs of infected individuals and encompasses diverse clinical manifestations. Ĭoronavirus disease 2019 (COVID-19) has spread worldwide. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The authors have no funding and conflicts of interests to disclose.ĭata sharing not applicable to this article as no datasets were generated or analyzed during the current study. Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis in a COVID-19 patient: a case report. ![]() How to cite this article: Kogure C, Kikushima W, Fukuda Y, Hasebe Y, Takahashi T, Shibuya T, Sakurada Y, Kashiwagi K. ∗Correspondence: Wataru Kikushima, Department of Ophthalmology, University of Yamanashi, Shimokato 1110, Chuo, Yamanashi 409-3898, Japan (e-mail: ).Ībbreviations: BCVA = best-corrected visual acuity, COVID-19 = coronavirus disease 2019, CSF = cerebrospinal fluid, HFA = Humphrey Field Analyzer, IgG = immunoglobulin G, MOG = myelin oligodendrocyte glycoprotein, MOGAD = MOG antibody disorder, MRI = magnetic resonance imaging, ON = optic neuritis, PCR = polymerase chain reaction, SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2. ADepartment of Ophthalmology, University of Yamanashi, Chuo, YamanashiīDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, MiyagiĬDepartment of Neurology, National Hospital Organization Yonezawa National Hospital, Yonezawa, YamagataĭShibuya Eye Clinic, Fujikawa, Yamanashi, Japan.
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